Announcing the 2025 Warren Alpert Foundation Prize Awardees Learn more

Celebrating the Transformative Impact of Computer Tools and Databases in Biomedicine

Each year the recipient(s) of the Warren Alpert Foundation Prize are recognized at a scientific symposium hosted by Harvard Medical School.

2023 Warren Alpert Foundation Prize Symposium

In honor of: David J. Lipman MD Senior Science Advisor for Bioinformatics and Genomics Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration for his vision and generation of computational tools, databases and infrastructure that changed the way biological information can be rapidly and freely exchanged, searched, and analyzed, thus enabling discovery of fundamental biological mechanisms, their alterations in disease, and potential as new therapeutic targets.

David Lipman

David Lipman | 2023 Recipient

Dr. David Lipman worked at the National Institutes of Health for 36 years and served as the founding Director of the National Center for Biotechnology Information (NCBI) at the National Library of Medicine/NIH. Under Dr. Lipman’s leadership, NCBI created and managed some of the most heavily used biomedical information resources including PubMed, PubMed Central, GenBank, SRA, and RefSeq. In 2014, Dr. Lipman also led the team at NCBI that developed the computational genomics resources used by the FDA and CDC to identify foodborne outbreaks more rapidly and to determine the source of contamination. He is currently Senior Science Advisor in Bioinformatics and Genomics at FDA’s Center for Food Safety and Applied Nutrition.

From 2017 through 2019, Dr. Lipman served as Chief Science Officer for plant-based meat company Impossible Foods. He directed the team that developed and commercialized the current Impossible Burger, the Impossible Whopper, and the sausage and ground pork formulations.

Dr. Lipman’s research has focused on molecular evolution, molecular epidemiology, comparative genomics, and the development of computational tools including the computational tool, BLAST, for biological sequence comparison and database search. His research papers have been cited by over 250,000 scientific publications. Dr. Lipman is an elected member of the National Academy of Sciences, the National Academy of Medicine, and the American Academy of Arts and Sciences.

Symposium Program

Each year the recipient(s) of the Warren Alpert Foundation Prize are recognized at a scientific symposium hosted by Harvard Medical School.

Watch the full program

Opening Remarks

George Q. Daley, MD,

Dean of the Faculty of Medicine, Harvard University; Caroline Shields Walker Professor of Medicine

Vamsi Mootha, MD

Professor of Systems Biology, Harvard Medical School and Massachusetts General Hospital; Investigator, Howard Hughes Medical Institute

Award Lecture

David J. Lipman, MD

Invited Speakers

Eugene V. Koonin, PhD

Distinguished Investigator, Evolutionary Genomics Group Leader; National Institutes of Health

Debora Marks, PhD

Professor of Systems Biology, Harvard Medical School; Associate Member, Broad Institute of MIT and Harvard

David C. Page, MD

Member, Whitehead Institute; Professor of Biology, Massachusetts Institute of Technology; Investigator, Howard Hughes Medical Institute

Olga Troyanskaya, PhD

Director, Princeton Precision Health; Professor in the Department of Computer Science and the Lewis-Sigler Institute for Integrative Genomics, Princeton University; Deputy Director for Genomics, Flatiron Institute’s Center for Computational Biology

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Past Symposia

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I am truly honored to be a recipient of the Alpert Award. It is especially meaningful to be recognized by my colleagues for discoveries that helped define the biology of the CTLA-4 and PD-1 pathways. The clinical translation of our fundamental understanding of these pathways illustrates the value of basic science research, and I hope this inspires other scientists.
- Arlene Sharpe

Arlene Sharpe | 2017 Recipient

Dr. Sharpe received her A.B. from Harvard University, where she did undergraduate thesis research in the laboratory of Dr. Jack Strominger.  She received her M.D. and Ph.D. degrees from Harvard Medical School where she did PhD thesis research on reovirus pathogenesis in the laboratory of Dr. Bernard Fields. She completed residency training in Pathology at Brigham and Women’s Hospital and postdoctoral research in the laboratory of Dr. Rudolf Jaenisch at the Whitehead Institute.

She currently is the George Fabyan Professor of Comparative Pathology, Head of the Division of Immunology, and Interim Co-Chair of the Department of Microbiology and Immunobiology at Harvard Medical School. She is a member of the Department of Pathology at Brigham and Women’s Hospital, an Associate Member at the Broad Institute of MIT and Harvard, and Leader of the Cancer Immunology Program at the Dana-Farber/Harvard Cancer Center. Dr. Sharpe is the Co-Director of the Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital. She has served as a member and chair of the NIH Hypersensitivity, Autoimmunity and Immune-mediated diseases (HAI) study section and is currently a member of NIAID Council. She is also the President of the American Association of Immunologists.

Dr. Sharpe’s functional analysis of costimulatory pathways regulating T cell activation has led to understanding of (1) the roles of B7-1 and B7-2 as positive regulators through CD28 and (2) negative regulators through CTLA-4, and (3) the role of PD-L1 and PD-L2 as negative regulators through PD-1. This functional characterization has provided critical translational insights that underpinned development of immunotherapies for cancer, autoimmune diseases, and transplant rejection.

Dr. Sharpe’s laboratory currently investigates the roles of T cell costimulatory and coinhibitory pathways in regulating T cell tolerance and effective antimicrobial and antitumor immunity, and translating fundamental understanding of T cell costimulation into new therapies for autoimmune diseases and cancer. Dr. Sharpe has published over 300 papers and was listed by Thomas Reuters as one of the most Highly Cited Researchers (top 1%) in 2014 and 2015 and a 2016 Citation Laureate. She received the William B. Coley Award for Distinguished Research in Tumor immunology in 2014 for her contributions to the discovery of PD-1 pathway.

 View Past Recipients