Celebrating the Transformative Impact of Computer Tools and Databases in Biomedicine

Each year the recipient(s) of the Warren Alpert Foundation Prize are recognized at a scientific symposium hosted by Harvard Medical School.

2023 Warren Alpert Foundation Prize Symposium

In honor of: David J. Lipman MD Senior Science Advisor for Bioinformatics and Genomics Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration for his vision and generation of computational tools, databases and infrastructure that changed the way biological information can be rapidly and freely exchanged, searched, and analyzed, thus enabling discovery of fundamental biological mechanisms, their alterations in disease, and potential as new therapeutic targets.

David Lipman

David Lipman | 2023 Recipient

Dr. David Lipman worked at the National Institutes of Health for 36 years and served as the founding Director of the National Center for Biotechnology Information (NCBI) at the National Library of Medicine/NIH. Under Dr. Lipman’s leadership, NCBI created and managed some of the most heavily used biomedical information resources including PubMed, PubMed Central, GenBank, SRA, and RefSeq. In 2014, Dr. Lipman also led the team at NCBI that developed the computational genomics resources used by the FDA and CDC to identify foodborne outbreaks more rapidly and to determine the source of contamination. He is currently Senior Science Advisor in Bioinformatics and Genomics at FDA’s Center for Food Safety and Applied Nutrition.

From 2017 through 2019, Dr. Lipman served as Chief Science Officer for plant-based meat company Impossible Foods. He directed the team that developed and commercialized the current Impossible Burger, the Impossible Whopper, and the sausage and ground pork formulations.

Dr. Lipman’s research has focused on molecular evolution, molecular epidemiology, comparative genomics, and the development of computational tools including the computational tool, BLAST, for biological sequence comparison and database search. His research papers have been cited by over 250,000 scientific publications. Dr. Lipman is an elected member of the National Academy of Sciences, the National Academy of Medicine, and the American Academy of Arts and Sciences.

Symposium Program

Each year the recipient(s) of the Warren Alpert Foundation Prize are recognized at a scientific symposium hosted by Harvard Medical School.

Watch the full program

Opening Remarks

George Q. Daley, MD,

Dean of the Faculty of Medicine, Harvard University; Caroline Shields Walker Professor of Medicine

Vamsi Mootha, MD

Professor of Systems Biology, Harvard Medical School and Massachusetts General Hospital; Investigator, Howard Hughes Medical Institute

Award Lecture

David J. Lipman, MD

Invited Speakers

Eugene V. Koonin, PhD

Distinguished Investigator, Evolutionary Genomics Group Leader; National Institutes of Health

Debora Marks, PhD

Professor of Systems Biology, Harvard Medical School; Associate Member, Broad Institute of MIT and Harvard

David C. Page, MD

Member, Whitehead Institute; Professor of Biology, Massachusetts Institute of Technology; Investigator, Howard Hughes Medical Institute

Olga Troyanskaya, PhD

Director, Princeton Precision Health; Professor in the Department of Computer Science and the Lewis-Sigler Institute for Integrative Genomics, Princeton University; Deputy Director for Genomics, Flatiron Institute’s Center for Computational Biology

Sign up to receive updates

Sign up to receive updates

Past Symposia

For questions about the prize, please contact us.

Contact Us
I feel deeply honored to receive this prestigious award in recognition of the research I conducted with my extraordinary coworkers over many years. I hope the award will promote fundamental basic research for future applications we have not the slightest idea about yet
- Peter Hegemann

Peter Hegemann | 2019 Recipient

Peter Hegemann is a Hertie professor for neuroscience and head of Experimental Biophysics at Humboldt-Universitaet zu Berlin. Hegemanns research focused almost entirely on the characterization of natural sensory photoreceptors. Hegemann has characterized behavioral and photoelectric responses of the unicellular alga Chlamydomonas, a work that cumulated in the claim that the photoreceptors for these responses a rhodopsins that unify the sensor and ion channel in one protein. He has finally proven this concept by identifying the light gated channel channelrhodopsin, and its functionality in animal cells.

His group characterized this protein in molecular detail by a wide range of biophysical techniques; in close collaboration with Karl Deisseroth this lead to the deciphering of the ion channel mechanism, including gating and ion selection. This work was the basis for the discovery of Optogenetics, a technology where light activated proteins – first of all channelrhodopsin - allow to control selected cells of large networks as the animal brain with unprecedented precision in space and time just by application of light. The Hegemann group also works on light-activated enzymes which further expand the optogenetic applications to important biochemical pathways.

 View Past Recipients